Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the common squamous cell carcinomas of the head and neck, and 70 to 85% of cases are already in advanced stage when diagnosed due to the hidden location of the onset. Our findings suggest that c-Jun is a reliable prognostic factors in HPSCC patients. The Cox proportional multivariate hazard model revealed that lymphovascular invasion and c-Jun expression were independent influencing factors of OS in HPSCC patients.

The expression of c-Jun high ( p = 0.0043), p-c-Jun high ( p = 0.0376) and c-Jun high/p-c-Jun high were closely associated with poor OS. High expression of c-Jun was closely associated with cT stage ( p = 0.0401), tumor size ( p = 0.0276), number of lymph node metastases ( p = 0.0205) and pathological differentiation ( p = 0.0108). The high expression of c-Jun and p-c-Jun in HPSCC accounted for 60.61% and 16.16%, respectively. Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan–Meier method and multivariate Cox regression analysis. The expression of c-Jun and phosphorylated-c-Jun (p-c-Jun) was evaluated via immunohistochemistry (IHC) staining.

MethodsĪ retrospective study was performed on a cohort of 99 HPSCC patients. To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC).

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